A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.

@article{Wu2012ANS,
  title={A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.},
  author={Hongbing Wu and Jianxu Li and Qizhi Zhang and Xiluan Yan and Liangran Guo and Xiaoling Gao and Ming-feng Qiu and Xinguo Jiang and Ren Lai and HongZhuan Chen},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2012},
  volume={80 2},
  pages={368-78}
}
Because of the immunogenicity and toxicity in vivo of large molecules such as lectins, the application of these molecules is remarkably restricted in drug delivery systems. In this study, to improve the brain drug delivery and reduce the immunogenicity of traditional lectin modified delivery system, Odorranalectin (OL, 1700 Da), a novel non-immunogenic small peptide, was selected to establish an OL-modified cubosomes (Cubs) system. The streptavidin (SA)-conjugated Cubs were prepared by… CONTINUE READING

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Bi-Botti C

  • D. Bei, J. N. Meng
  • Youan, Engineering nanomedicines for improved…
  • 2010
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