A novel signaling pathway impact analysis

@article{Tarca2009ANS,
  title={A novel signaling pathway impact analysis},
  author={Adi L. Tarca and Sorin Draghici and Purvesh Khatri and Sonia S. Hassan and Pooja Mittal and Jung-sun Kim and Chong Jai Kim and Juan Pedro Kusanovic and Roberto Romero},
  journal={Bioinformatics},
  year={2009},
  volume={25 1},
  pages={
          75-82
        }
}
MOTIVATION Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result of such experiments can be approached, for instance, by identifying the signaling pathways impacted by the observed changes. Most of the existing pathway analysis methods focus on either the number of DE genes observed in a given pathway (enrichment analysis methods), or on the correlation between the… CONTINUE READING

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