A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.

@article{Dodelet1999ANS,
  title={A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.},
  author={Vincent C Dodelet and Claudia Pazzagli and Andreas Hugo Zisch and C. A. Hauser and Elena B Pasquale},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 45},
  pages={31941-6}
}
The Eph family of receptor tyrosine kinases has been implicated in many developmental patterning processes, including cell segregation, cell migration, and axon guidance. The cellular components involved in the signaling pathways of the Eph receptors, however, are incompletely characterized. Using a yeast two-hybrid screen, we have identified a novel signaling intermediate, SHEP1 (SH2 domain-containing Eph receptor-binding protein 1), which is expressed in the embryonic and adult brain. SHEP1… CONTINUE READING
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