A novel serum protein similar to C1q, produced exclusively in adipocytes.

@article{Scherer1995ANS,
  title={A novel serum protein similar to C1q, produced exclusively in adipocytes.},
  author={Phillip E Scherer and Scott Allan Williams and Michael Fogliano and Giulia Baldini and Harvey L. Lodish},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 45},
  pages={
          26746-9
        }
}
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by… CONTINUE READING
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