A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice.

@article{Wang1998ANS,
  title={A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice.},
  author={Junru R Wang and Congran Li and He Zen Yang and Arcady Mushegian and Shouguang Jin},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 24},
  pages={6764-8}
}
A genetic locus of Pseudomonas aeruginosa was identified that is highly and specifically inducible during infection of neutropenic mice. This locus, ppkA, encodes a protein that is highly homologous to eukaryote-type serine/threonine protein kinases. A ppkA null mutant strain shows reduced virulence in neutropenic mice compared to the wild type. Overexpression of the PpkA protein greatly inhibited the growth of Escherichia coli or P. aeruginosa. However, a single amino acid change at the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 13 references

from Streptomyces coelicolor A 3 ( 2 )

  • A. Mushegian, S. Lory, S. Jin
  • 1996

Similar Papers

Loading similar papers…