A novel series of potent and selective agonists at the opioid kappa-receptor.

Abstract

Three novel opioid agonists are described. These compounds were found to bind with high affinity and selectivity to the kappa-opioid receptor. Isolated tissue studies using the field-stimulated mouse vas deferens and guinea-pig ileum preparations confirmed the high agonist potency and naloxone-reversibility of these agents. All three compounds exhibited potent antinociceptive activity in the mouse abdominal constriction model. These compounds should prove useful as tools to investigate kappa-receptor function.

Cite this paper

@article{Costello1988ANS, title={A novel series of potent and selective agonists at the opioid kappa-receptor.}, author={Gerard F Costello and Brian G. M. Main and James J. Barlow and Jessica A. Carroll and Jaime Shaw}, journal={European journal of pharmacology}, year={1988}, volume={151 3}, pages={475-8} }