A novel sequence-based approach to localize translocation breakpoints identifies the molecular basis of a t(4;22).

@article{Nimmakayalu2003ANS,
  title={A novel sequence-based approach to localize translocation breakpoints identifies the molecular basis of a t(4;22).},
  author={Manjunath A. Nimmakayalu and Anthony L. Gotter and Tamim H. Shaikh and Beverly S Emanuel},
  journal={Human molecular genetics},
  year={2003},
  volume={12 21},
  pages={2817-25}
}
Low copy repeats (LCRs) located in 22q11.2, especially LCR-B, are susceptible to rearrangements associated with several relatively common constitutional disorders. These include DiGeorge syndrome, Velocardiofacial syndrome, Cat-eye syndrome and recurrent translocations of 22q11 including the constitutional t(11;22) and t(17;22). The presence of palindromic AT-rich repeats (PATRRs) within LCR-B of 22q11.2, as well as within the 11q23 and 17q11 regions, has suggested a palindrome-mediated, stem… CONTINUE READING

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