A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

@article{Clausen2006ANS,
  title={A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.},
  author={Rasmus Praetorius Clausen and Bente Fr\olund and Orla Miller Larsson and Arne Schousboe and Povl Krogsgaard-Larsen and Henry S White},
  journal={Neurochemistry international},
  year={2006},
  volume={48 6-7},
  pages={637-42}
}
The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. This transport system is an important therapeutical target in epileptic disorders, but potentially also in other neurological disorders. Thus, selective intervention in GABA uptake has been the subject of extensive research for several decades. In a series of lipophilic diaromatic derivatives of (RS)-3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole… CONTINUE READING

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