A novel secreted splice variant of vascular endothelial cell growth inhibitor.

@article{Chew2002ANS,
  title={A novel secreted splice variant of vascular endothelial cell growth inhibitor.},
  author={L -J Chew and Hongguang Pan and Jingyi Yu and Song Tian and Wei-qun Huang and John Y Zhang and Shen Pang and Lu-Yuan Li},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2002},
  volume={16 7},
  pages={742-4}
}
Vascular endothelial cell growth inhibitor (VEGI), a member of the tumor necrosis factor (TNF) family, is an endothelial cell-specific inhibitor of angiogenesis. Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression, but overexpression of full-length VEGI was completely without effect. This finding indicates that secretion is essential for VEGI action. Here we report the identification of two new VEGI isoforms consisting of 251… CONTINUE READING