A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages.

@article{Geurtsen2007ANS,
  title={A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages.},
  author={Jeroen Geurtsen and Eline Angevaare and Marlieke Janssen and Hendrik-Jan Hamstra and Jan Bart Ten Hove and Alex de Haan and Betsy Kuipers and Jan P Tommassen and Peter van der Ley},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 52},
  pages={
          37875-84
        }
}
Lipopolysaccharide is one of the major constituents of the Gram-negative bacterial outer membrane and is a potent stimulator of the host innate immune response. The biosynthesis of the lipid A moiety of lipopolysaccharide is a complex process in which multiple gene products are involved. Two late lipid A acyl transferases, LpxL and LpxM, were first identified in Escherichia coli and shown to be responsible for the addition of secondary acyl chains to the 2' and 3' positions of lipid A… CONTINUE READING

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