A novel salt bridge mechanism highlights the need for nonmobile proton conditions to promote disulfide bond cleavage in protonated peptides under low-energy collisional activation.

@article{Lioe2007ANS,
  title={A novel salt bridge mechanism highlights the need for nonmobile proton conditions to promote disulfide bond cleavage in protonated peptides under low-energy collisional activation.},
  author={Hadi Lioe and Richard A J O'Hair},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2007},
  volume={18 6},
  pages={1109-23}
}
The gas-phase fragmentation mechanisms of small models for peptides containing intermolecular disulfide links have been studied using a combination of tandem mass spectrometry experiments, isotopic labeling, structural labeling, accurate mass measurements of product ions, and theoretical calculations (at the MP2/6-311 + G(2d,p)//B3LYP/3-21G(d) level of… CONTINUE READING