A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.

@article{Francis2013ANR,
  title={A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.},
  author={Shimon P. Francis and Joshua Katz and Kathryn D Fanning and Kimberly A. Harris and Brian D. Nicholas and Michael Lacy and James M. Pagana and Paul F. Agris and Jung-Bum Shin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 7},
  pages={3079-93}
}
Ototoxicity is a main dose-limiting factor in the clinical application of aminoglycoside antibiotics. Despite longstanding research efforts, our understanding of the mechanisms underlying aminoglycoside ototoxicity remains limited. Here we report the discovery of a novel stress pathway that contributes to aminoglycoside-induced hair cell degeneration. Modifying the previously developed bioorthogonal noncanonical amino acid tagging method, we used click chemistry to study the role of protein… CONTINUE READING
Highly Cited
This paper has 30 citations. REVIEW CITATIONS