A novel role of complement in retinal degeneration.

@article{Yu2012ANR,
  title={A novel role of complement in retinal degeneration.},
  author={Minzhong Yu and Weilin Zou and Neal S Peachey and Thomas M McIntyre and Jinbo Liu},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 12},
  pages={
          7684-92
        }
}
PURPOSE The association of single nucleotide polymorphisms of components of the complement alternative pathway with the risk of age-related macular degeneration (AMD) indicates that complement signaling plays an important role in retinal physiology. How genetic variation leads to retinal degeneration is unknown. It has been assumed that complement activation augments immune responses, which in turn initiate AMD pathogenesis. To better understand the relationship between complement and the outer… CONTINUE READING

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