A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.

@article{Sawhney2009ANR,
  title={A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.},
  author={Rajinder S. Sawhney and Wensheng Liu and Michael G. Brattain},
  journal={Journal of cellular physiology},
  year={2009},
  volume={219 1},
  pages={
          152-61
        }
}
In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrin-mediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when metastatic MDA-MB-231 and PC-3 cells were plated on VN was enhanced. Further experiments showed co-immunoprecipitation of integrins beta1, alpha V beta 3, or alpha V beta 5 with ERK5 and FAK. To gain better insight… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

The Role of ERK5 in Cell Proliferation

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

MAP Kinases and Prostate Cancer

  • Journal of signal transduction
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Impact of ERK5 on the Hallmarks of Cancer

  • International journal of molecular sciences
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

MEK 5-ERK 5 Signaling in Cancer : Implications for Targeted Therapy

Van T. Hoang, Thomas J. Yan, +4 authors Matthew E. Burow
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND