A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons

@inproceedings{Peng2010ANR,
  title={A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons},
  author={Shu-Chun Peng and Yen-Ting Lai and Hsi-Yuan Huang and Hsien-Da Huang and Yi-Shuian Huang},
  booktitle={Nucleic acids research},
  year={2010}
}
CPEB3 is a sequence-specific RNA-binding protein and represses translation of its target mRNAs in neurons. Here, we have identified a novel function of CPEB3 as to interact with Stat5b and inhibit its transcription activity in the nucleus without disrupting dimerization, DNA binding and nuclear localization of Stat5b. Moreover, CPEB3 is a nucleocytoplasm-shuttling protein with predominant residence in the cytoplasm; whereas activation of NMDA receptors accumulates CPEB3 in the nucleus. Using… CONTINUE READING