A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.

@article{Nishimura2005ANR,
  title={A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.},
  author={Hitoshi Nishimura and Toshiki Yajima and Hiromi Muta and Eckhard R. Podack and Kenzaburo Tani and Yasunobu Yoshikai},
  journal={Journal of immunology},
  year={2005},
  volume={175 7},
  pages={4627-34}
}
Memory CD8+ T cells can be divided into two subsets, central memory (T(CM)) and effector memory (T(EM)) CD8+ T cells. We found that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR superfamily, signaling is involved in differentiation of long-lived CD8+ T(CM) cells following Listeria monocytogenes infection. Although CD8+ T(EM) cells transiently accumulated in the nonlymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ T(CM) cells were poorly… CONTINUE READING

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