A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets

@article{Cheng2011ANR,
  title={A novel role for vitamin D: modulation of expression and function of the local renin–angiotensin system in mouse pancreatic islets},
  author={Qianni Cheng and Yan Li and Barbara J. Boucher and Prof. P. S. Leung},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={2077-2081}
}
The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or without calcitriol were examined for changes in RAS component activity and glucose-stimulated insulin secretion (GSIS). Isolated islets from vitamin D receptor knockout (VDR-KO) mice were compared with islets… CONTINUE READING

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