A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila.

@article{Dow1994ANR,
  title={A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila.},
  author={Julian A. T. Dow and S H P Maddrell and Shireen A. Davies and N J V Skaer and Kim Kaiser},
  journal={The American journal of physiology},
  year={1994},
  volume={266 5 Pt 2},
  pages={R1716-9}
}
The nitric oxide (NO) signaling pathway plays major roles in the vertebrate vascular, nervous, and immune systems. Here we present evidence that all the elements in the NO pathway are present in, and act to control epithelial fluid secretion by, the Malpighian tubules of an insect, Drosophila melanogaster. This finding will allow both a physiological and a molecular genetic dissection of the NO pathway in the same tissue. 

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