A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells.

@article{Choong2003ANR,
  title={A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells.},
  author={Meng Ling Choong and Amabel C. L. Tan and Biao Luo and Harvey F. Lodish},
  journal={FEBS letters},
  year={2003},
  volume={550 1-3},
  pages={155-62}
}
A family of proliferin genes was discovered on a microarray analysis of hematopoiesis supportive stromal cell lines. Proliferin-2 (PLF2) increased the frequency of long-term culture-initiating cells (LTC-IC) from 1 in 340 to 1 in 256 of the primary hematopoietic stem cell (HSC)-enriched bone marrow cells grown on MS5.1 feeder layer. A repeat using AFT024 feeder layer also showed a similar increase in LTC-IC (from 1 in 386 cells to 1 in 260 cells). The clonogenic output of the LTC-ICs was also… CONTINUE READING

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