A novel role for neutrophils as critical activators of NK cells.

  title={A novel role for neutrophils as critical activators of NK cells.},
  author={Roman Sp{\"o}rri and Nicole Joller and Hubert Hilbi and Annette Oxenius},
  journal={Journal of immunology},
  volume={181 10},
Neutrophils are essential players in innate immune responses to bacterial infection. Despite the striking resistance of Legionella pneumophila (Lpn) to bactericidal neutrophil function, neutrophil granulocytes are important effectors in the resolution of legionellosis. Indeed, mice depleted of neutrophils were unable to clear Lpn due to a lack of the critical cytokine IFN-gamma, which is produced by NK cells. We demonstrate that this can be ascribed to a previously unappreciated role of… CONTINUE READING


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