A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ

@inproceedings{Tan2015ANR,
  title={A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ},
  author={Guosheng Tan and Xinping Cao and Qiangsheng Dai and Bing Zhang and Jianwen Huang and Shiqiu Xiong and Yong Zhang and Wei Chen and Jianyong Yang and Heping Li},
  booktitle={Oncotarget},
  year={2015}
}
Transcriptional co-activator Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are key oncogenes in mammalian cells. Activities of YAP and TAZ are largely restricted by the Hippo tumor suppressor pathway through phosphorylation-ubiquitination mechanisms. The involvement of microRNA in cancer progression has recently been reported, though whether they have a role in activating YAP and TAZ in human cancer cells remains unclear. Here, we report a microRNA… CONTINUE READING
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