A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone.

@article{Huang2001ANR,
  title={A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone.},
  author={H J Huang and Joyce C Wu and Pei Qi Su and Oleg P. Zhirnov and William L. Miller},
  journal={Endocrinology},
  year={2001},
  volume={142 6},
  pages={2275-83}
}
FSH is produced in pituitary gonadotropes as an alpha/beta heterodimer, and synthesis of the beta-subunit is the rate-limiting step in overall FSH production. Synthesis of FSHbeta can be regulated by activin and inhibin, both of which are members of the transforming growth factor-beta superfamily. Bone morphogenetic proteins (BMPs) also belong to the transforming growth factor-beta family and are multifunctional growth factors involved in many aspects of tissue development and morphogenesis… CONTINUE READING

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