A novel role for WAVE1 in controlling actin network growth rate and architecture

@inproceedings{Sweeney2015ANR,
  title={A novel role for WAVE1 in controlling actin network growth rate and architecture},
  author={Meredith O. Sweeney and Agnieszka Collins and Shae B. Padrick and Bruce L. Goode},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Branched actin filament networks in cells are assembled through the combined activities of Arp2/3 complex and different WASP/WAVE proteins. Here we used TIRF and electron microscopy to directly compare for the first time the assembly kinetics and architectures of actin filament networks produced by Arp2/3 complex and dimerized VCA regions of WAVE1, WAVE2, or N-WASP. WAVE1 produced strikingly different networks from WAVE2 or N-WASP, which comprised unexpectedly short filaments. Further analysis… CONTINUE READING
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References

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Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 4 Excerpts
Highly Influenced

Processive acceleration of actin barbed-end assembly by N-WASP

Molecular biology of the cell • 2014
View 12 Excerpts
Highly Influenced

Motility determinants in WASP family proteins.

Molecular biology of the cell • 2002
View 4 Excerpts
Highly Influenced

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