A novel role for Twist-1 in pulp homeostasis.

  title={A novel role for Twist-1 in pulp homeostasis.},
  author={Kerstin M Galler and Akihiro Yasue and Adriana C. Cavender and Peter E Bialek and Gerard Karsenty and Rena N D'Souza},
  journal={Journal of dental research},
  volume={86 10},
The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotypic changes that involved an earlier onset of dentin matrix formation, increased alkaline phosphatase activity, and pulp stones within the pulp. RT-PCR analyses revealed Twist-1… CONTINUE READING