A novel rhodopsin phosphodiesterase from Salpingoeca rosetta shows light-enhanced substrate affinity.

@article{Tian2018ANR,
  title={A novel rhodopsin phosphodiesterase from Salpingoeca rosetta shows light-enhanced substrate affinity.},
  author={Yuehui Tian and Shiqiang Gao and Shang Hsien Yang and Georg Nagel},
  journal={The Biochemical journal},
  year={2018},
  volume={475 6},
  pages={1121-1128}
}
It is since many years textbook knowledge that the concentration of the second messenger cGMP is regulated in animal rod and cone cells by type II rhodopsins via a G-protein signaling cascade. Microbial rhodopsins with enzymatic activity for regulation of cGMP concentration were only recently discovered: in 2014 light-activated guanylyl-cyclase opsins in… CONTINUE READING