A novel rhodopsin kinase in octopus photoreceptor possesses a pleckstrin homology domain and is activated by G protein betagamma-subunits.

@article{Kikkawa1998ANR,
  title={A novel rhodopsin kinase in octopus photoreceptor possesses a pleckstrin homology domain and is activated by G protein betagamma-subunits.},
  author={Shinichi Kikkawa and Nobuko Yoshida and Masashi Nakagawa and Tatsuo Iwasa and Motoyuki Tsuda},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 13},
  pages={7441-7}
}
G protein-coupled receptor kinases (GRKs) play an important role in stimulus-dependent receptor phosphorylation and desensitization of the receptors. Mammalian rhodopsin kinase (RK) and beta-adrenergic receptor kinase (betaARK) are the most studied members among known GRKs. In this work, we purified RK from octopus photoreceptors for the first time from invertebrate tissues. The molecular mass of the purified enzyme was 80 kDa as estimated by SDS-polyacrylamide gel electrophoresis, and this was… CONTINUE READING