A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.

@article{Katakai2004ANR,
  title={A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.},
  author={Tomoya Katakai and Takahiro Hara and Jong-Hwan Lee and Hiroyuki Gonda and Manabu Sugai and Akira Shimizu},
  journal={International immunology},
  year={2004},
  volume={16 8},
  pages={1133-42}
}
For efficient adaptive immunity, the lymph nodes (LNs) are equipped with a strategically organized microarchitecture, which is largely supported by the reticular network (RN). The RN can be clearly visualized by fluorescence immunohistochemistry coupled with confocal imaging using a monoclonal antibody, ER-TR7, and can be subdivided into four structurally distinct regions, each of which correlates well with the location of distinct immune cell subsets. In addition, we noticed a characteristic… CONTINUE READING
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