A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.

@article{VanGompel2010ANR,
  title={A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.},
  author={Michael J. W. VanGompel and Eugene Yujun Xu},
  journal={Human molecular genetics},
  year={2010},
  volume={19 12},
  pages={2360-9}
}
Reproduction is required for the survival of all animals, yet few reproductive genes have been shown to have a conserved requirement for fertility across the animal kingdom. Remarkably, the RNA binding protein BOULE, the oldest member of the DAZ (Deleted in AZoospermia) family of genes, appears to have maintained its conserved functional motif and spermatogenic expression from insects to humans. Boule mutations lead to a pachytene meiotic arrest before metaphase in Drosophila males and C… CONTINUE READING