A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish

@article{Shimizu2002ANR,
  title={A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish},
  author={Takashi Shimizu and Yojiro Yamanaka and Hideaki Nojima and Taijiro Yabe and Masahiko Hibi and Toshio Hirano},
  journal={Mechanisms of Development},
  year={2002},
  volume={118},
  pages={125-138}
}
Dharma/Bozozok (Dha/Boz) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in zebrafish dorsal organizer formation. Dha/Boz interacted with a co-repressor Groucho through the Eh1 motif. Expression of a Dha/Boz fused to the transcriptional activator VP16 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/vega1, indicating that Dha/Boz functions as a… CONTINUE READING
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