A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis

@inproceedings{VilasBoas2011ANR,
  title={A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis},
  author={Filipe Vilas-Boas and Rita Fior and Jason R. Swedlow and Kate G Storey and Domingos Henrique},
  booktitle={BMC Biology},
  year={2011}
}
Building the complex vertebrate nervous system involves the regulated production of neurons and glia while maintaining a progenitor cell population. Neurogenesis starts asynchronously in different regions of the embryo and occurs over a long period of time, allowing progenitor cells to be exposed to multiple extrinsic signals that regulate the production of different cell types. Notch-mediated cell-cell signalling is one of the mechanisms that maintain the progenitor pool, however, little is… CONTINUE READING