A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

  title={A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.},
  author={H. Hamada and M. G. Petrino and T. Kakunaga},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={79 21},
By Southern blotting and hybridization analysis using 32P-labeled poly(dT-dG) . poly(dC-dA) as a probe, we have found, in eukaryotic genomes, a huge number of stretches of dT-dG alternating sequence, a sequence that has been shown to adopt the Z-DNA conformation under some conditions. This sequence was found in all eukaryotic genomes examined from yeast to human, indicating extraordinary evolutionary conservation. The number of the sequence ranged from about 100 in yeast to tens of thousands in… Expand
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