A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation.

@article{Ponce2013ANR,
  title={A novel reduced-intensity conditioning regimen induces a high incidence of sustained donor-derived neutrophil and platelet engraftment after double-unit cord blood transplantation.},
  author={Doris M Ponce and Craig S Sauter and Sean M. Devlin and Marissa N. Lubin and Anne Marie R Gonzales and Nancy A Kernan and Andromachi Scaradavou and Sergio Giralt and Jenna D. Goldberg and Guenther Koehne and Miguel Angel Perales and James W Young and Hugo Castro-Malaspina and Ann A. Jakubowski and Esperanza B. Papadopoulos and Juliet Barker},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2013},
  volume={19 5},
  pages={799-803}
}
A preparative regimen of reduced intensity that can reliably engraft cord blood (CB) and can be used as an alternative to either high-dose myeloablative or nonmyeloablative conditioning is needed. We evaluated double-unit CB transplantation in 30 patients (median age, 56 years; range, 18 to 69) with acute leukemia or myelodysplasia using a regimen of cyclophosphamide 50 mg/kg, fludarabine 150 mg/m(2), thiotepa 10 mg/kg, and 400 cGy total body irradiation with cyclosporine-A/mycophenolate… CONTINUE READING
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Advances and Controversies in Hematopoietic Transplantation and Cell Therapy • 2017
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Optimal Practices in Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2017

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