A novel recombinant soluble human thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers.

@article{Nakashima1998ANR,
  title={A novel recombinant soluble human thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers.},
  author={Mitsuyoshi Nakashima and Toshihiko Uematsu and Kazuo Umemura and Itaru Maruyama and Kazuhisa Tsuruta},
  journal={Journal of clinical pharmacology},
  year={1998},
  volume={38 6},
  pages={540-4}
}
The effect of a novel recombinant soluble human thrombomodulin, ART-123, on protein C activation was investigated by measuring plasma prothrombinase activity in four healthy male volunteers. ART-123 at a dose of 0.3 mg was administered as a bolus intravenous injection for 1 minute. Plasma ART-123 concentration and prothrombinase activity were determined… CONTINUE READING