A novel recombinant lineage’s contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013

Abstract

Since late 2012, coxsackievirus A6 (CVA6) has gradually become the predominant pathogen responsible for hand-foot-mouth disease (HFMD) in several provinces of China. A total of 626 patients diagnosed with HFMD in Shanghai, China from January 2012 to September 2013 were enrolled in this study. Of these, 292 CVA6 infected cases were subjected to clinical analyses. Whole-genome sequencing, recombination and phylogenetic analyses were also performed. A recombinant CVA6 monophyletic lineage was found during an outbreak of CVA6-associated HFMDs in Shanghai, China in November 2012, and accounted for 21.9% (64/292) of the CVA6 strains during the study period. Recombination analyses showed that the 2C gene of the novel CVA6 virus was probably derived from a coxsackievirus A4 (CVA4) strain circulating in the population. Clinical observation showed that this recombinant CVA6 virus led to a more generalized rash than did the non-recombinant CVA6 virus. This newly emerged CVA6 lineage was associated with a considerable proportion of HFMD cases from 2012 to 2013 in Shanghai, and poses a potential threat to public health.

DOI: 10.1038/srep11700

Extracted Key Phrases

4 Figures and Tables

Statistics

020040020162017
Citations per Year

113 Citations

Semantic Scholar estimates that this publication has 113 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Feng2015ANR, title={A novel recombinant lineage’s contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013}, author={Xiaobo Feng and Wencai Guan and Yifeng Guo and Huiju Yu and Xiaoling Zhang and Ruhong Cheng and Zhen Wang and Zhen Zhang and Jia Zhang and Huaguo Li and Yin Zhuang and Hui Zhang and Zhiyong Lu and Ming Li and Hong Yu and Yixiao Bao and Yunwen Hu and Zhirong Yao}, booktitle={Scientific reports}, year={2015} }