A novel receptor involved in T-cell activation

@article{Cocks1995ANR,
  title={A novel receptor involved in T-cell activation},
  author={Benjamin G. Cocks and Chia-Chun J. Chang and J Carballido and Hans Yssel and Jan E. De Vries and Gregorio Aversa},
  journal={Nature},
  year={1995},
  volume={376},
  pages={260-263}
}
OPTIMAL T-cell activation and T-cell expansion require triggering by T-cell antigen receptors and co-stimulatory signals provided by accessory cells1á¤-3. A major co-stimulatory pathway involves crosslinking the CD28 molecule on T cells by its ligands CD80 or CD86 expressed on antigen-presenting cells4á¤-7. But recent studies8,9 on CD28-deficient mice have indicated that CD28 is not required for all T-cell responses and that additional T-cell co-stimulatory pathways exist. Here we describe a… 

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References

SHOWING 1-10 OF 23 REFERENCES

Functional expression of B7/BB1 on activated T lymphocytes

TLDR
Activated T cells can coexpress both CD28 and its counter-receptor, B7, which suggests that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway.

T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2.

TLDR
The portion of CD2 involved in CD2-dependent signaling and in the regulation of avidity for its ligand CD58 is mapped to structurally distinct portions of the cytoplasmic domain to analyze the contribution of co-receptor basal adhesion, signaling, and avidity regulation in antigen-dependent T cell interactions.

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.

TLDR
A counter-receptor of CD28 and CTLA-4 is cloned, termed B7-2, which also costimulates IL-2 production and T cell proliferation and is likely to provide a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.

Differential T cell costimulatory requirements in CD28-deficient mice.

TLDR
CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist.

B70 antigen is a second ligand for CTLA-4 and CD28

TLDR
It is indicated that B70 is a second ligand for CD28 and CTLA-4 and may play an important role for costimulation of T cells in a primary immune response.

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

TLDR
It is shown that the CD28 antigen, expressed in Chinese hamster ovary cells, mediated specific intercellular adhesion with human lymphoblastoid and leukemic B-cell lines and with activated primary murine B cells, and represents a heterophilic interaction between members of the immunoglobulin superfamily that may serve to regulate T-cell cytokine levels at sites of B- cell activation.

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand.

We cloned the human CD40 ligand (hCD40L) from a cDNA library constructed from an activated CD8+T cell clone. Two cDNAs representing a 2.1 and a 1.4 kb clone were detected. Both cDNA clones had

The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation

TLDR
It is reported that the 26-kD transmembrane form of tumor necrosis factor alpha (mTNF-alpha), which is rapidly expressed on CD4+ T cell clones after activation, contributes to the costimulatory signals resulting in IL-4-dependent Ig synthesis by B cells, including IgG4 and IgE production.