A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.

@article{Ruat1993ANR,
  title={A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.},
  author={M. Ruat and E. Traiffort and J. Arrang and J. Tardivel-Lacombe and J. D{\'i}az and R. Leurs and J. Schwartz},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={193 1},
  pages={
          268-76
        }
}
Using a strategy based upon nucleotide sequence homology and starting from the sequence of the rat histamine H2 receptor (Ruat et al., Biochem. Biophys. Res. Commun. 1991, 179, 1470-1478), we have cloned a rat cDNA encoding a functional serotonin receptor (5-HT6). Its coding sequence corresponds to a glycoprotein of 436 amino acids displaying significant homology with other cloned monoaminergic receptors, e.g., various serotonin receptors. Genomic analysis of its gene indicated the presence of… Expand
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