A novel quinone antibiotic from Malbranchea cinnamomea TAIM 13T54.

  title={A novel quinone antibiotic from Malbranchea cinnamomea TAIM 13T54.},
  author={Yin-Mei Chiung and Tomoyuki Fujita and Masahira Nakagawa and Hiroshi Nozaki and G. Y. Chen and Z C Chen and Mitsuru Nakayama},
  journal={The Journal of antibiotics},
  volume={46 12},
A novel quinone antibiotic named malbranicin was isolated from the culture filtrate and mycelium of Malbranchea cinnamomea TAIM 13T54, a thermophilic fungus. The antibiotic was elucidated to be 6-(1-acetylethyl)-2-methoxy-2,5-cyclohexadiene-1,4-dione by spectral analysis. Malbranicin exhibited antimicrobial and cytotoxic activities against Gram-positive bacteria and mammalian cell lines, respectively. 

Figures and Tables from this paper

New quinones and hydroquinones from Malbranchea cinnamomea HKI 286 and HKI 296 and interaction with Tax/CREB expression system in yeast.
New substituted quinones 2, 3, 6 and hydroquinone 4 were isolated from the culture brothes of two strains of Malbranchea cinnamomea and the chemical constitutions of new metabolites were elucidated by optical spectroscopy, mass spectrometry and 1D/2D NMR spectroscopic.
Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase.
All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus strains and vancomycin-resistant Enterococci.
α-Glucosidase Inhibitors from Malbranchea flavorosea.
From an extract prepared from the grain-based culture of Malbranchea flavorosea two new polyketides were isolated, namely, 8-chloroxylarinol A and flavoroseoside, and the X-ray structure of compound 6 is reported for the first time.
Keratinophilic Fungi Distribution, Pathogenicity and Biotechnological Potentials
Keratinophilic fungi in different habitats wherein the population of these fungi is expected to occur: air, soil from various environments like gardens, caves, cold and saline habitat are discussed.
Molecular Analysis of a 4-Dimethylallyltryptophan Synthase from Malbranchea aurantiaca*
This study provides a detailed characterization of a prenyltransferase in Malbranchea species, reveals two enzyme inhibitors, and through site-directed mutagenesis identified several key amino acid residues in catalysis, yielding new insights into this important yet understudied class of natural product biosynthetic enzymes.
Diversity of biologically active secondary metabolites in the ascomycete order Sordariales
This work summarizes for the first time relevant information about the available knowledge on the secondary metabolites and the biological activities exerted by representatives of this fungal order, as well as a current outlook of the potential opportunities that the recent advances in omic tools could bring for the discovery of secondary metabolites in this order.
Pharmaceutical Applications of Thermophilic Fungi
  • G. S. Prasad
  • Biology, Engineering
    Fungi in Extreme Environments: Ecological Role and Biotechnological Significance
  • 2019
Although thermophilic fungi form a diverse group of organisms and their incidence was reported from different substrates like mushroom compost, municipal waste, dung material, and coal mine soil, their application in pharmaceutical industry is unexplored.


Thermophilic and Thermotolerant Fungi in Taiwan (II)
從臺灣之臺東地區稻田土壤中分離出嗜熱性真菌一種,Rhizomucor miehei (Cooney and Emerson)Schipper,及耐熱性真菌一種,Rhizopus microsporus v. Tiegh. var. rhizopodiformis(Cohn)Schipper and Stalpers,皆為臺灣菌類相之新記錄。
Chapter 2. Indentification
  • In The Naturally Occurring Quinones
  • 1971