A novel quantitative immunohistochemistry method for precise protein measurements directly in formalin-fixed, paraffin-embedded specimens: analytical performance measuring HER2

@article{Jensen2017ANQ,
  title={A novel quantitative immunohistochemistry method for precise protein measurements directly in formalin-fixed, paraffin-embedded specimens: analytical performance measuring HER2},
  author={Kristian Jensen and Rikke Krusenstjerna-Hafstr\om and Jesper Lohse and Kenneth Heesche Petersen and Helene D{\'e}rand},
  journal={Modern Pathology},
  year={2017},
  volume={30},
  pages={180-193}
}
In clinical routine pathology today, detection of protein in intact formalin-fixed, paraffin-embedded tissue is limited to immunohistochemistry, which is semi-quantitative. This study presents a new and reliable quantitative immunohistochemistry method, qIHC, based on a novel amplification system that enables quantification of protein directly in formalin-fixed, paraffin-embedded tissue by counting of dots. The qIHC technology can be combined with standard immunohistochemistry, and assessed… CONTINUE READING
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