A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.

@article{Tsubaki2000ANP,
  title={A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.},
  author={Koji Tsubaki and Kiyoshi Taniguchi and Seiichiro Tabuchi and Osamu Okitsu and Kouji Hattori and Jiro Seki and Kazuo Sakane and Hirokazu Tanaka},
  journal={Bioorganic & medicinal chemistry letters},
  year={2000},
  volume={10 24},
  pages={2787-90}
}
A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.