A novel putative tyrosine kinase receptor with oncogenic potential.

  title={A novel putative tyrosine kinase receptor with oncogenic potential.},
  author={J. W. Janssen and Ansgar S Schulz and Ada C. M. Steenvoorden and Monika Schmidberger and Sabine Strehl and Peter F. Ambros and Claus Rainer Bartram},
  volume={6 11},
We have detected transforming activity by a tumorigenicity assay using NIH3T3 cells transfected with DNA from a chronic myeloproliferative disorder patient. Here, we report the cDNA cloning of the corresponding oncogene, designated UFO, in allusion to the as yet unidentified function of its protein. Nucleotide sequence analysis of a 3116bp cDNA clone revealed a 2682-bp-long open reading frame capable of directing the synthesis of a 894 amino acid polypeptide. The predicted UFO protein exhibits… CONTINUE READING


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