A novel pseudoknot element is essential for the action of a yeast telomerase.

  title={A novel pseudoknot element is essential for the action of a yeast telomerase.},
  author={Yehuda Tzfati and Zachary A Knight and Jagoree Roy and Elizabeth H Blackburn},
  journal={Genes & development},
  volume={17 14},
Telomerase contains an essential RNA, which includes the template sequence copied by the reverse transcription action of telomerase into telomeric DNA. Using phylogenetic comparison, we identified seven conserved sequences in telomerase RNAs from Kluyveromyces budding yeasts. We show that two of these sequences, CS3 and CS4, are essential for normal telomerase function and can base-pair to form a putative long-range pseudoknot. Disrupting this base-pairing was deleterious to cell growth… CONTINUE READING

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