A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases.

@article{Esposito1999ANP,
  title={A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases.},
  author={Teresa Esposito and Fernando Gianfrancesco and Alfredo Ciccodicola and Luisa Montanini and Steve Mumm and Michele D'Urso and Antonino Forabosco},
  journal={Human molecular genetics},
  year={1999},
  volume={8 1},
  pages={
          61-7
        }
}
We report the cloning of a novel gene, called Tramp, in the Xp/Yp PAR region that has a functional homologue on the Y chromosome and escapes X-inactivation. This gene encodes, within a single exon, a putative protein that has amino acid similarity with transposases of the Ac family. Flanking this gene we have identified putative terminal inverted repeats (TIRs) and a duplicate target site, suggesting that it may be an ancient transposable element. The nucleotide differences in these sites and… CONTINUE READING
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