A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.

@article{Gaggar2008ANP,
  title={A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.},
  author={Amit Gaggar and Patricia L. Jackson and Brett D. Noerager and Philip J. O'Reilly and Douglas Brent McQuaid and Steven M. Rowe and J. Patrick Clancy and James Edwin Blalock},
  journal={Journal of immunology},
  year={2008},
  volume={180 8},
  pages={
          5662-9
        }
}
Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix proteins, such as collagen and elastin, play an important role in inflammatory cell recruitment to the lung in animal models of airway inflammation. Unfortunately, the association of these peptides with human disease and the identification of therapeutic targets directed toward these inflammatory pathways have… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2007
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Biomechanics of lung parenchyma: critical role for collagens and mechanical forces

B. Suki, S. Ito, D. Stamenovic, K. R. Lutchen, E. P. Enginito
  • J. Appl. Physiol
  • 2005
VIEW 1 EXCERPT

Cystic fibrosis.

  • The New England journal of medicine
  • 2005
VIEW 3 EXCERPTS