A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

@article{Seeger1998ANP,
  title={A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.},
  author={Michael Seeger and Robert Kraft and Katherine Ferrell and Dawadschargal Bech-Otschir and Renate Dumdey and Ruediger Schade and Colin G. Gordon and Michael Naumann and Wolfgang Dubiel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1998},
  volume={12 6},
  pages={469-78}
}
A novel protein complex has been identified in human cells that has a molecular mass of approximately 450 kDa. It consists of at least eight different subunits including JAB1, the Jun activation-domain binding protein 1, and Trip15, the thyroid hormone receptor-interacting protein 15. The purified complex contains COP9 and COP11 protein homologs and is very similar, if not identical, to the plant COP9 complex involved in light-mediated signal transduction. The isolated JAB1-containing particle… CONTINUE READING
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