A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.

Abstract

Protease-activated receptor-1 (PAR1) is a G protein-coupled receptor that plays critical roles in cancer, angiogenesis, inflammation, and thrombosis. Proteolytic cleavage of the extracellular domain of PAR1 generates a tethered ligand that activates PAR1 in an unusual intramolecular mode. The signal emanating from the irreversibly cleaved PAR1 is terminated… (More)
DOI: 10.1074/jbc.M110.105403

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