A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives.

@article{Sarzani1999ANP,
  title={A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives.},
  author={Riccardo Sarzani and Paolo Dess{\`i}-Fulgheri and F. Salvi and Massimiliano Serenelli and D Spagnolo and Giovanna Cola and Mauro Pupita and L Giantomassi and Alessandro Rappelli},
  journal={Journal of hypertension},
  year={1999},
  volume={17 9},
  pages={
          1301-5
        }
}
OBJECTIVE AND DESIGN The clearance receptor for natriuretic peptides (NPRC), a candidate gene for essential hypertension, is highly expressed in adipose tissue, where is nutritionally regulated. The objectives of the present study were to sequence the human 5'-flanking regulatory region of NPRC, to identify allelic variants and their frequencies, and to study the genotype/phenotype correlation in hypertensive patients. METHODS AND RESULTS Using polymerase chain reaction (PCR) and direct… CONTINUE READING
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