A novel predictive score for hepatocellular carcinoma development in patients with chronic hepatitis C after sustained response to pegylated interferon and ribavirin combination therapy.

@article{Chang2012ANP,
  title={A novel predictive score for hepatocellular carcinoma development in patients with chronic hepatitis C after sustained response to pegylated interferon and ribavirin combination therapy.},
  author={Kuo-Chin Chang and C. -J. Hung and Sheng-Nan Lu and Jing-Houng Wang and C. -H. Lee and Chien-Hung Chen and Ming-Fang Yen and Sheng-Chieh Lin and Yi-Hao Yen and Ming-Chao Tsai and Po-lin Tseng and Tsung-Hui Hu},
  journal={The Journal of antimicrobial chemotherapy},
  year={2012},
  volume={67 11},
  pages={2766-72}
}
OBJECTIVES Antiviral therapy can prevent the development of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients. However, HCC still develops in patients achieving sustained virological response (SVR). We proposed to evaluate the risk factors and derive a novel risk score for HCC (score(HCC)) by summation of products of clinical weights based on the regression coefficients in the final proportional hazards model. METHODS From March 2002 to October 2009, we enrolled 871… CONTINUE READING
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