A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein

@inproceedings{Mousa2017ANP,
  title={A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein},
  author={Jarrod J. Mousa and Nurgun Kose and Pranathi Matta and Pavlo Gilchuk and James E. Crowe},
  booktitle={Nature Microbiology},
  year={2017}
}
Respiratory syncytial virus (RSV) remains a major human pathogen, infecting the majority of infants before age two and causing re-infection throughout life. Despite decades of RSV research, there is no licensed RSV vaccine. Most candidate vaccines studied to date have incorporated the RSV fusion (F) surface glycoprotein, because the sequence of F is highly conserved among strains of RSV. To better define the human B cell response to RSV F, we isolated from a single donor 13 new neutralizing… CONTINUE READING
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