A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase.

@article{Wall1997ANP,
  title={A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase.},
  author={Erika M. Wall and Jing Xin Cao and Ning Chen and R. Mark L. Buller and Chris Upton},
  journal={Virus research},
  year={1997},
  volume={52 2},
  pages={157-67}
}
A novel poxvirus gene has been characterized within the genome of ectromelia virus. It has significant similarity to a family of lysophospholipases suggesting that it may function in the degradation of lysophospholipids. Since these molecules are active in the stimulation of inflammation, we hypothesize that this gene may play a role in virus virulence. This gene is expressed early in the ectromelia virus replication cycle, before DNA replication. We have also characterized a human cDNA that… CONTINUE READING