A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression.

@article{Singh2014ANP,
  title={A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression.},
  author={Amar Bahadur Singh and Chin Fung Kelvin Kan and Vikram Ravindra Shende and Bin Dong and Jingwen Liu},
  journal={Journal of lipid research},
  year={2014},
  volume={55 7},
  pages={
          1397-407
        }
}
It is well-established that over-accumulation of dietary cholesterol in the liver inhibits sterol-regulatory element binding protein (SREBP)-mediated LDL receptor (LDLR) gene transcription leading to a reduced hepatic LDLR mRNA level in hypercholesterolemic animals. However, it is unknown whether elevated cholesterol levels can elicit a cellular response to… CONTINUE READING